BIOC 300B Lecture Notes - Lecture 28: Phosphorylase, Hydrolase, Allosteric Regulation
6 Apr 2018
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Lecture 28: glycogen metabolism supplementary information: describe the structure of glycogen and its roles in the liver and muscle. Distinguish between -1,4-glycosidic linkages and their -1,6-glycosidic isomers. Glycogen is the storage form of glucose, and therefore consists of several glucose monomers linked together by -1,4 linkages, and branched by -1,6- glycosidic linkages. Storage of glucose in the liver is important for maintaining blood-glucose homeostasis and feeding the brain. Pound for pound, there is the most glycogen in the liver, but there is more glycogen found in the muscles because you have more muscles than liver. Glycogen enables anaerobic metabolism when glucose is limiting: list the properties of glycogen granules. There is a higher organization of glycogen into granules. Glycogen phosphorylase: phosphorolytic reaction that requires orthophosphate to release one monosaccharide of glucose at a time. The released glucose is activated" with the phosphate group glucose-1- phosphate. Will release glucose without falling off of the granule.
