Class Notes (1,100,000)
CA (650,000)
UVic (3,000)
CHEM (200)
Hoff (5)
Lecture 20

CHEM 437 Lecture Notes - Lecture 20: Ic50, Chloroquine, Ethosuximide


Department
Chemistry
Course Code
CHEM 437
Professor
Hoff
Lecture
20

This preview shows half of the first page. to view the full 2 pages of the document.
Chem 437!
Key Terms:!
!
Pharmacokinetics:!
!
Three PK parameters:!
1) Clearance!
2) Volume of distribution!
3) Half-life!
______________________________________________________________________________________
_______!
Clearance!1.
!
CL= The "volume" of blood cleared of drug per unit time!
!
CL determines dose and frequency for a drug!
High CL= lots of wasted drug!
!
How to measure clearance:!
!
A) Renal clearance!
#!
#CL= U*V/C!
# !
U= concentration of drug in blood or urine (mg/L)!
V= Urine flow rate (L/h)!
C= As above (mg/L)!
!
Note: U* V = urine elimination rate (mg/h)!
!
B) Single IV Dose, observe C over time!
!
CL= Dose/AUC## (L/hour)= total dose(mg)/ AUC (mg*hour/L)!
!
AUC=Integral of the plasma drug concentration-time curve!
!
C) Steady State IV
!
CL= Dose Rate/ Css (steady state)!
______________________________________________________________________________________
____!
Case Study!
-shows the importance of having a drug stay in the system long enough, however, lost IC50
potency!
!
###IC50### # CL# # # !
Lead###0.26nM# # 170 mL/min/kg!
End project#1.0 nM# # 62 mL/min/kg!
!
6.3 Volume of Distribution:
You're Reading a Preview

Unlock to view full version