EPHE 245 Lecture Notes - Lecture 15: Long-Term Potentiation, Tetanus, Sprouting

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(cid:862)(cid:374)euro(cid:374)s that fire together, wire together(cid:863: a skill (memory) is the strength (weight) of this connection, learning (or forgetting) changes the strength of these connections. We learn from repetition (more receptor sites, structural changes, more nt) skill improvement =long term potentiation. Step 1: weak stimulus input 1 to establish baseline. Step 2: give strong stimulus (tetanus) in same fibers (arrows) Step 3: continue weak stimulation to record increased responses. Step 4: throughout, check for responses in control fibers. Repetition of things creates ltp as well. Input only occurs where an input generates it. Ltp results when synaptic stimulation coincides with postsynaptic depolarization (achieved by cooperativity of many coactive synapses during tetanus, called cooperativity) The timing of the postsynaptic response relative to the synaptic units is critical. Ltp has he(cid:271)(cid:271)ia(cid:374) (cid:272)hara(cid:272)teristi(cid:272)s (cid:894)(cid:862)what fires together, wires together,(cid:863) or i(cid:374) this (cid:272)ase, connected together more strongly.

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