5-350 Lecture Notes - Megacolon, Transactivation, Apoptosis

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NEURAL CREST CELLS
NCC originate in ridges of neural folds during gastrulation
Form all of PNS
Coelesce into ganglia
migration involves epithelial mesenchymal transition
origin = dorsal margin of neural tube,
ventral to surface epithelium
How is NCC fate specified?
requires signals from ectoderm AND dorsal neural tube
WNT-6 BMP
early expression of NOELIN-1 is a determinant of NCC diff.
secreted by neural folds and migrating NCC
SLUG = NCC marker
HNK-1 = antibody for NCC
neolin-retrovirus will upregulate slug expression
NCC fates:
Cranial NCC: teeth
heart septum
pharyngeal cartilage
cranial nerve
conn. tiss. around eye
dermis/hypodermis
FACE (Cranial NCC cranial mesenchyme)
Cranial/Spinal: schwann cells, glial cells
melanocytes
enteric ganglia
arachnoid/pia matter
Spinal: adrenal medulla
pre-aortic ganglia
dorsal root ganglia (DRG)
chain ganglia
Wnt6, BMP
Noelin-1
Slug
Hnk-1
cranial
mesenchyme
DRG
chain ganglia
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