5-350 Lecture Notes - Tx Network, Zygote

• School: University of Windsor
• Department: Biological Sciences
• Course: 5-350
• Professor: Asish Mukhopadhyay

Document Summary

Maternal genes determine a/p and d/v axes, which regulate . Zygotic gap genes begin to set up segmentation, which regulate . Zygotic pair-rule genes establish finer segments, which regulate. Zygotic segment polarity genes establish direction of each segment. All three zygotic gene classes regulate homeotic genes, which direct development of each segment. Role is to roughly establish parasegments; each pair-rule gene is expressed in alternating parasegments. Multiple + and cis acting enhancers that respond to gap genes restrict. Stripe patterns are out of phase, so each row expresses different combination of. Pair-rule genes are txn factors that control expression of segment polarity genes: example 1: expression of hairy in stripe 6. Only a single hairy gene; different upstream regulatory sequences that control expression in each stripe. Hairy is activated by knirps but is outcompeted by kruppel repression, which completely determines where the hairy stripe is: example 2: expression of eve in stripe 2.