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55-101 (38)
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Lecture

Development IV

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Department
Biological Sciences
Course
55-101
Professor
Habetler
Semester
Fall

Description
Outline of Lecture 18 (02-21 E; Ginty) Development IV I. Function and mode of cell death in nervous system development - 4 functions of cell death: systems matching, error correction, sexual dimorphism, remove transient cells - Neuron death generally occurs during target recognition due to lack of trophic support from target tissue - Neurotrophic hypothesis: competition over limited supply of neurotrophic factor from target tissue leads to death of incorrectly targeted neurons - Many cells provide trophic support, but the major ones are target-derived - Glial cells also die during development, perhaps requiring trophic support from axons II. Cell biology of apoptosis (general) - Apoptosis is ATP-dependent and is clean and controlled; necrosis is not - C. elegans worm is a classis system to study apoptosis; its genes are highly homologous to vertebrate apoptotic genes - Understand the role of Bcl-2, Bax, cytochrome C, APAF1, and caspases (Fig. 8 in notes) III. Nerve Growth Factor (NGF) is the prototypical neurotroph
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