Class Notes (839,556)
Canada (511,391)
55-101 (38)
Habetler (38)

Pain II

1 Page

Biological Sciences
Course Code

This preview shows half of the first page. Sign up to view the full page of the document.
Outline of Lecture 30 (02-27 B; Caterina) Pain II I. There are many types of noxious stimuli - Pain can be caused by mechanical, chemical, thermalndor electrical stimuli - Basic pathway is DRG synapses in dorsal horn to 2 order neuron, which projects to thalamus via STT, where it synapses to 3 order neuron to cortex - Endogenous chemical stimuli include pH, ATP, K, histamine, and inflammatory products - There are exogenous compounds that can also cause pain - Prostaglandins and leukotrienes mediate hyperalgesia - NSAIDs mediate their affects by inhibiting cycloxygenase (part of prost. pathway) - COX I is expr in a wide variety of tissues, including gut, mediates GI protection - COX II has restricted expr, excluding gut, and mediates inflammation - COX II selective drugs ought to be anti-inflammatory w/o irritating gut - COX III mediates CNS effects on pain and fever - Some C fibers release CGRP and substance P, causes neurogenic inflammation and further pain stimulation (positive feedback) II. Transduction of noxious stimuli to action potential - Transduction of stimulus to action potential relies on ionotropic and metabotropic receptors - Modulation of nociception relies on GPCRs and neurotrophin receptors - Nociceptive neurons exhibit considerable molecular and functional heterogeneity A) ION CHANNELS - Ligand: ATP, serotonin, etc. can activate specific ligand gated ion channels - pH: Acid-sensing ion channels (ASICs) are Na channels sensitive to drops in pH - Heat: TRPV1 is stimulated at 43°C, but is also sensitive to capsaicin and H+ - Mechanical: ASIC a
More Less
Unlock Document

Only half of the first page are available for preview. Some parts have been intentionally blurred.

Unlock Document
You're Reading a Preview

Unlock to view full version

Unlock Document

Log In


Join OneClass

Access over 10 million pages of study
documents for 1.3 million courses.

Sign up

Join to view


By registering, I agree to the Terms and Privacy Policies
Already have an account?
Just a few more details

So we can recommend you notes for your school.

Reset Password

Please enter below the email address you registered with and we will send you a link to reset your password.

Add your courses

Get notes from the top students in your class.