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Cerebellum II

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Biological Sciences
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Outline of Lecture 48 (03-11 B; Linden) Cerebellum II Narrative summary of the lecture: This lecture describes a model for how the cerebellum circuitry gives rise to conditioned learning. The basic cerebellar circuit is shown in Figure 1—memorize it. It consists of the usual neuronal components, but of added importance is the type of synapses. PF-PC, CF-PC, and MF-DCN synapses are excitatory, whereas PC-DCN and CF-DCN synapses are inhibitory. The cerebellar circuit can be seen as a negative feedback control loop for motor signaling through the DCN. In the Marr/Albus model, a mechanism for associative eyeblink conditioning can be directly mapped onto the cerebellar circuit: - Parallel fibers carry the conditioned stimulus - Climbing fibers carry the unconditioned stimulus - Disinhibition of the DCN gives rise to the conditioned response Since LTD of the PF-PC synapse via CF-PC association results in DCN disinhibition, the model proposes that such LTD is the cause of eyeblink conditioni
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