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Lecture

BLOOD: Functions

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School
University of Windsor
Department
Biological Sciences
Course
55-140
Professor
Habetler
Semester
Fall

Description
BLOOD: Functions – nutrient/oxygen delivery maintain vascular integrity (clotting factors) defense of organism Proliferation and differentiation: all cells from a common stem cell that either differentiates or divides differentiation is irreversible and eventually leads to cell death (not division) Pluripotent Lymphoid (immunity) Myeloid (rest of blood) growth factors (CSF’s) dictate all steps of differentiation Disease: too much: leukemia/lymphoma too little : anemia’s ERYTHROCYTES: 40% of blood 120d lifetime Red Cell Maturation: Pronormoblast  Basophilic normoblast  polychromatic  orthrochromatic (can no longer divide)  reticulocyte reticulocyte: contain polyribosomes, mitochondria, but mostly HG RBC: no nucleus, only HG biconcave disk b/c of cytoskeleton; still quite flexible spherocytosis: ball shaped b/c of cytoskeleton disorder PLATELETS: 10d lifespan “cellular plugs” come from MEGAKARYOCYTE lumenal extensions in bone marrow discoid shape maintained by cytoskeleton granules (recruit other platelets for clotting) activate clotting cascade also (leads to fibrin formation) tissue repair role (platelet derived growth factor) MYELOMONONUCLEAR CELLS – from myeloblasts can migrate bet
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