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55-140 (56)
Habetler (53)
Lecture

GLYCOGEN METABOLISM

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Department
Biological Sciences
Course
55-140
Professor
Habetler
Semester
Fall

Description
GLYCOGEN METABOLISM glycogen – approx 1 day’s worth of stored energy liver – highest concentration glycogen here serves as buffer rapidly depleted upon fasting GLUCOSE 6 PHOSPHATASE – allows release of glucose after it is broken off glycogen as glucose 6 phosphate (which is impermeable to cell membranes); liver/kidney only muscle – highest amt glycogen here is for energy. rapidly depleted upon exercise glycogen is branched  allows for compactness increases rates of storage/release glycogen is a glycoprotein and is highly hydrated  inefficient for large amts of energy storage GLYCOGEN DEGRADATION: 1) GLYCOGEN PHOSPHORYLASE – phosphorylitic cleavage of glycogen results in glycogen and G1P requires PLP – pyridoxal phosphate **phosphate involved in cleavage (takes H+ from H PO ), 2 4 promoting the attack on the glycosidic oxygen** distance between glycogen binding (storage) and cleavage (active) sites limits distance between cleavages to 4 residues 2) GLYCOSYL TRANSFERASE removes 3 residues after branch and puts them on other end of glycogen also has an a16 glucosidase that hydrolyzes glucose at branch, releasing free glucose 3) PHOSPHOGLUCOMUTASE: adds phosphate at C6, removes at C1 G6P can enter glycolysis be dephosphorylated and exported (liver only) enter pentose phosphate pathway **reversible enzyme** (used in both glycognesis and lysis) DEGRADATION REGULATION –
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