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55-140 (56)
Habetler (53)
Lecture

FATTY ACID OXIDATION

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Department
Biological Sciences
Course
55-140
Professor
Habetler
Semester
Fall

Description
LIPID MOBILIZATION / FATTY ACID OXIDATION fat is great as a storage fuel - not hydrated - insoluble aggregate - 9 kcal/g dietary fat  CHYLOMICRONS (TG’s; made in intestine)  liver, fat fat synth in liver  VLDL to fat FFA in adipose  Liver, Muscle, Kidneys, Heart (NOT Brain, RBC’s) LIPOPROTEIN LIPASE: chylomicron  FA + glycerol (capillary lumen of adipocytes) Mobilization of TG’s from FAT TISSUE: all act to INC intracellular cAMP - fasting - exercise - diabetes - low temp cAMP  PKA activation PKA phos. HSL, perlipin cAMP also causes translocation of HSL to fat droplet FFA’s inhibit HSL insulin activates cAMP phosphodiesterase  dec cAMP free glycerol must be exported b/c no a-GLYCEROPHOSPHATE  no TG synth B-OXIDATION Occurs in mitochondria of: muscle (heart, skeletal) liver (for ketogenesis) 1. FA Activation by THIOKINASE R-CO2  R-CO-AMP  R-CO-SCoA 2. entry into IM space by CPT1 R-CO-SCoA  R-COO-carnitine **inhibited by malonyl CoA (FA synth intermediate) ** 3. entry into matrix by CPT2 R-COO-carnitine
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