BIOL 1111 Lecture Notes - Muscarine, Nerve Agent, Bradycardia

• School: University of Windsor
• Department: Biological Sciences
• Course: BIOL 1111
• Professor: Habetler

Document Summary

Monoamines i: there are three basic criteria for proving a substance is a nxt, sufficient: substance mimics endogenous response, necessary: receptor antagonist block response due to substance, presence: substance is the endogenous agent (e. g. can be isolated/purified) Catalyzed by choline acetyltransferase: high affinity choline uptake into presyn, ach synthesis in cytoplasm, vesicular ach transporter. Catalyzed by ach-esterase (ache: muscarine: muscarinic receptor agonist, atropine: muscarinic receptor antagonist, reverses bradycardia, nerve gas: irreversible inhibitor of. Ache: curare: nicotinic receptor antagonist, paralyzes diaphragm and skeletal muscles, muscarinic: parasympathetic, 5 subtypes, (e. g. m2 expr by heart), all. Tyr dopa dopamine ne (ne epi, in adrenal medulla) High affinity ne uptake: cocaine: blocks ne uptake, tachycardia. All gpcr: a : smooth muscles (e. g. vascular bp effects, b : sympathetic to heart. Subtypes not listed here (from this, be able to predict agonist/antagonist effects) The 2 major nxt of the autonomic system are ach and ne.