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Lecture

Development

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Department
Biological Sciences
Course
55-140
Professor
Habetler
Semester
Fall

Description
Outline of Lecture 11 (02-20 D; Ghosh) Development II I. Neural induction: the notochord plays a key role A) Quick review - During gastrulation, dorsal tissue migrates through blastopore lip to become mesoderm - Notochord forms from mesoderm, and induces ectodermal neural plate formation B) Neural induction - Default fate of ectodermal cells is neuronal; BMP4 induces epidermal fate - Notochord produces noggin, chordin to inhibit BMP4, thereby inducing neural diffn - Notochord produces Shh a ventralizing morphogen that acts in a graded manner: high Shh (most ventral) induces motoneurons, intermediate induces interneurons, low produces commissural neurons - Roof plate produces BMP2, a dorsalizing morphogen - Neurons are produced by lateral walls of neural tube, NOT the roof or floor plate II. Neurogenesis A) Ventricular zone: site of neurogenesis - Asymmetric divisions (parallel to base) give rise to neurons, whereas symmetric divisions (perpendicular to base) do not - Neurons are generated early and glial cells are generated later - Neuroblasts
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