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55-213 (36)
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55-213 Lecture 23 notes.pdf
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Department
Biological Sciences
Course
55-213
Professor
Hubberstey
Semester
Winter

Description
Lecture 23 20130110 229 PM Importantconceptsforweek13 Howischromatinremodeledo StructureofchromatinisimportantforDNAreplicationandtranscription RoleofsmallRNAsingeneregulation WilldiscusshowweturngenesonandoffitsacomplicatedsystemChromatinremodelingingeneregulation Whatcontrolshistonechanges DNAiswrappedupinhistonesallthetime HistonesaremodifiedbyacetylationmethylationphosphorylationthesechangeitsabilitytointeractwiththeDNAandthetranscriptionapparatustohaveaccesstoparticularDNAsequences TheseprocessesareconstantlychangingbackandforthandtheyplayamajorroleintheabilityofRNApolymerasetocontrolagene Sowhatcontrolstheseparticularhistonechangeso HistoneshavetocomeofftheDNAandtogetRNApolymerasepastacertainpointinDNAhistoneshavetoberemoved Seefigure2815DynamicModel Theydonteasilycomeoff UsingATPhydrolysishistonescanbereleasedformDNAandotherproteinscanthenbind ThisprocessrequiresenergytoripthehistonesofftheDNA Seefigure2816nucleosomedisplacementisanactiveprocess Thisisaremodelingcomplex
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