55-140 Lecture Notes - Glycogen, Tx Network, Table Tennis

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Published on 1 Feb 2013
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GLUCONEOGENESIS
tissues reliant upon glucose
- neural
- RBC
- kidney
- testes
factors leading to its activation
- fasting
- diabetes
- low CHO diet
- prolonged exercise
new glucose largely made from protein; some from glycerol
all blood glucose goes through the liver
- dietary
- glycogenic
- gluconeogenic (kidney also)
glucogenic substance: converted to glucose
detected in urine after PHLORIZIN treatment (lowers renal
threshold for glucose)
enzymes:
glucose 6 phosphatase (ER membrane, faces lumen)
FBPase (cytosol)
PEP carboxykinase (cytosol)
Pyruvate Carboxylase (mito matrix)
requires 4 ATP, 2GTP to go from 2 pyruvate glucose
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