55-140 Lecture Notes - Hemoglobin, Pyruvic Acid, Citric Acid Cycle

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GLYCOLYSIS:
1. Hexokinase/Glucokinase glucose G6P regulatory point
induced fit model
2. PhosphoHexose
Isomerase
G6P F6P
3. PhosphofructoKinase-1
(PFK1)
F6P F1,6BP **KEY regulatory point**
4. Aldolase F1,6BP DHAP + GAP
5. Triose Phosphate
Isomerase
DHAP GAP
6. GAP Dehydrogenase
(GAPDH)
GAP
1,3Bisphosphoglycerate
reduces NAD NADH
(NAD must be replenished)
7. Phosphoglycerate Kinase 1,3BPG + ADP
ATP + 3PG
**first ATP generating
step**
highly exergonic and
coupled with step 6
8. Phosphoglycerate Mutase 3PG 2PG
9. Enolase 2PG PEP
(phosphoenolpyruvate)
10. Pyruvate Kinase PEP + ADP
Pyruvate + ATP
**regulated step**
RBC’s:
1,3 BPG 2,3 BPG: binds hemoglobin and reduces oxygen affinity
2,3 BPG levels are elevated at high altitude, late pregnancy
2,3 BPG 3PG **ATP generating step is circumvented** (step 7 skipped)
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