55-140 Lecture Notes - Dermatitis, Pyridoxine, Nicotinamide Adenine Dinucleotide

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VITAMIN ACTION DEFICIENCY ACTIVE
FORM
WHERE
FOUND?
Niacin Dehydrogenation
(oxidation)
Dermatitis,
Dementia,
Diarrhea,
Death
Pellegra
NAD+ ubiquitous
Riboflavin Dehydrogenation Mouth Fissures phosphorylated
FMN
add ADP
FAD
ubiquitous
Thiamine Decarboxylation
of alpha-keto
carboxylic acids
Beri-Beri add PPi
TPPi
ubiquitous
(but very heat
sensitive)
Biotin Carboxylation Biocytin
Folic Acid MonoCarbon
Transfer
Fully Reduce
(add 4 H’s)
FH4
Green Plants
B12 Methyl Carrier,
Hydride Shifts
Anemia Corrin Ring?
Pyridoxine Transamination phosphorylated
Pantothenic
Acid
Acyl Group
Transfer
CoA
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