BIOL 3581 Lecture 11: Biotech Lecture 11 (Nov 28)
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You have done a genetic screen to identify genes controlling wings in an insect. Some of the mutants have no wings, some have short wings and others have larger than normal wings.
1a. (9 points) What type of mutation (e.g., amorph, hyopmorph, etc.) is most likely responsible for each class of phenotypes? Explain briefly. State whether you expect each to be recessive or dominant.
No wings:
Short wings:
Large wings:
Mutation | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 |
1 | - | + | + | + | - | + | + | + | + | + | + | + |
2 | - | + | + | + | - | + | - | + | - | + | + | |
3 | - | - | + | + | + | + | + | + | + | + | ||
4 | - | + | + | + | + | + | + | + | + | |||
5 | - | + | + | + | + | + | + | + | ||||
6 | - | + | - | + | - | + | + | |||||
7 | - | + | + | + | - | - | ||||||
8 | - | + | - | + | + | |||||||
9 | - | + | + | + | ||||||||
10 | - | + | + | |||||||||
11 | - | - | ||||||||||
12 | - |
1b. (2 points) How many genes causing the small wing phenotypes are revealed by this analysis? ___________
1c. (6 points) Which mutants belong to the same complementation groups?
1d. (3 points) Cloning of the gene causing the large wings phenotype reveals that is a growth regulator, which is a ubiquitous protein present in many different cell types. Suggest an hypothesis to explain why only the wings were large but not other tissues.
1.
__________ are fairly small organelles that provide a safe place within the cell to carry out certain biochemical reactions that generate harmful, highly reactive oxygen species. These chemicals are both generated and broken down in the same location.
Lysosomes |
Endosomes |
Peroxisomes |
Nucleosomes 2. Biologists cannot possibly study all living species. Instead, they try to understand cell behavior by studying a select subset of them. Which of the following characteristics are useful in an organism chosen for use as a model in laboratory studies?
|