Class Notes (808,753)
Canada (493,377)
59-110 (6)
Habetler (6)


2 Pages
Unlock Document

University of Windsor
Chemistry and Biochemistry

Pathogenesis: How Microorganisms Cause Disease  Damage or destroy host cells - e.g. HIV, Salmonella o Organism is taken up by epithelial cells in the intestine  HOST SPECIFIC: ligand on pathogen must fit onto receptor proteins on host  Some hosts are more susceptible than others because proteins depend on gene coding o Destroy brush border of microvilli o Host creates a ruffled surface / Invaded cells detach from intestinal wall, creating inflamed lesions / Secretion of large amounts of watery fluid into the lumen of the gut → diarrhoea  Produce toxic waste - e.g. Vibrio cholerae o Are harmless but produce harmful "exotoxins" - toxins released from the cell o Causes loss of chloride and hydrogencarbonate ions from the intestinal cells o Osmotic loss of up to 10 litres of water per day o Impaired absorption of water and salt from the gut o This explains severe watery diarrhoea and death from dehydration  Body's own immune response to the presence of microorganisms which produce the symptom o e.g. Mycobacterium tuberculosis o Body tries do destroy the invading bacteria o This causes inflammation and damage to the surrounding cells occur o Lesions may become hard or spongy, leaving "holes" in the lungs, sometimes damaging blood vessels  Some bacteria will cause all of the 3 ways above; Some require a large number of bacteria for a disease; Some will only a few number of
More Less

Related notes for 59-110

Log In


Don't have an account?

Join OneClass

Access over 10 million pages of study
documents for 1.3 million courses.

Sign up

Join to view


By registering, I agree to the Terms and Privacy Policies
Already have an account?
Just a few more details

So we can recommend you notes for your school.

Reset Password

Please enter below the email address you registered with and we will send you a link to reset your password.

Add your courses

Get notes from the top students in your class.