KINE 1050 Lecture Notes - Lecture 1: Hyperglycemia, Catecholamine, Blood Sugar

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From rest to active must increase energy production. Nervous system: fast response; short lived and localized effect. Endocrine system: all tissues and glands that secrete hormones into the blood which are transported to targets cells. Tissues and glands: hypothalamus, pituitary gland, thyroid/parathyroid glands, adrenal glands, kidneys, pancreas, ovaries/testes. Hormones: chemical messengers secreted by cells regulate and coordinate a wide range of functions. Steroid: chemically like cholesterol, derived from cholesterol, soluble in lipids, diffuse through membranes, secreted by: Cannot cross membranes: secreted by: thyroid adrenal medulla. Hormone actions: hormones contact all body tissues must have specific receptors (lock and key) Each cell has 2 000 -10 000 receptors: steroid receptors are in the cytoplasm or nucleus, non-steroid receptors are on the cell membrane. Steroid hormone and receptors: work by direct gene activation: hormone crosses cell membrane and binds to receptor, hormone enters nucleus and binds to dna, activates certain genes to make rna, rna enters cytoplasm to initiate protein synthesis.

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