KIN-3505 Lecture Notes - Coagulative Necrosis, Necrosis, Gangrene
12 Oct 2013
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Cell death: types, necrosis, apoptosis, necrosis: localized death, usually not intentional programmed cell death, 1) coagulative necrosis little cell disruption/rupture, cells maintain original form. Usually due to immediate loss of blood, which causes rapid deterioration of a cell. Dry gangrene: local tissue death with little bacterial growth: 2) liquifactive necrosis tissue dissolution due to massive and more persistant inflammatory processes (wbc mediated=pus). Seen in the brain, infections, coagulative necrosis. Wet gangrene: tissue death with bacterial growth. Adaptations of cells: 1) atrophy (decrease in size, physiological (predictable: aging, pathological (disordered state, 2) hypertrophy, increase in demand (physical activity, left ventrical: increased. Bp: hormone stimulation (gh, testosterone, gene expressions (myostatin deficiency, **all interrelated, hyperplasia (increase in # of cells, compensatory (callus, pathological (cancer, hormone induced (prostate and other repro. Organs: 4) metaplasia (replacement of one cell type for another, cancer staging (squamous columnar squamous, 5) dysplasia, abnormal changes to a cell size/shape/organization, 6) neoplasia: new growth (cancer)
