Anatomy and Cell Biology 3309 Lecture Notes - Lecture 2: Basal Body, Cytoskeleton, The Terminal

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Cell junctions: sites where specialized contacts can be recognized between cells or between a cell and the basement membrane. Tight (occluding) junctions: holds two plasma membranes together. Gap junctions: they appear as a gap in electromicrographs of two cells. Zonula = belt (they get the entire thing surrounded) Fascia = band (only 1 or 2-3 faces form the junction) Macula = spot (are like dots of space) 2nm length, but tight junctions hold the cells so tight that they are seen as a line o. Location: lateral domain near the apical domain o. Extracellular loops of transmembrane proteins (occludin and claudin) join extracellular loops of occludin and claudin of the neighbour cell. These are homotypic, so they interact with the same proteins on the other side. Intracellular loops of occludin and claudin are indirectly connected to actin filaments via other proteins o. Zonula occludens many tight junctions lined up that wrap all the way around the cell.

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