Anatomy and Cell Biology 4429A Lecture : Alzheimer's Disease
22 Dec 2011
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Document Summary
People are living longer - the bulk of people that are suffering from alzheimer"s disease is going to increase. Sporadic - we don"t really know where they come from but they can"t be traced to any lineage. Only real way to tell that it was actually ad is a post-mortem test. Amyloid plaques - aggregated and deposited in nervous tissue in the brain. The connection between these and ad are incidental but not causative. These proteins are found within the neuron bodies. They are an aggregated fiber and are found in a conformation that are not soluble. Clear that there isn"t anything special of the amyloid precursor protein. It is a type 1 membrane protein - there is only one transmembrane domain. App is a membrane protein and has only one transmembrane domain with the amino terminus inside the membrane. If you knock it out, the mice are normal.
