Anatomy and Cell Biology 4429A Lecture : Hypercholesterolemia
22 Dec 2011
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Statin works inhibit endogenous level of ldl synthesis. Statin drugs inhibit hmg-coa reductase which is the first step in the synthesis of cholesterol. Xanthoma - high cholesterol ends up being put in walls of tendons. Ldl receptor is the primary cause - at least 100 different mutations in this gene. Roughly speaking, if you have this disease, you must lower this cholesterol. Albumin binds fat and can transport it in the blood. Hmg-coa can be inhibited by purified ldl, which ends up with a biochemical negative feedback pathway. If i treat cells from patients with familial hypercholesteria, it doesn"t work. This signifies that this negative feedback control regulated by increased concentration of ldl does not work and is lost. These patients, however, did not have a defect in hmg-coa as one would think first. **i take ldl particles and determine how many of them have been taken up by radio- labelling them. This experiment showed that the binding was saturable.
