Anatomy and Cell Biology 4451F/G Lecture Notes - Lecture 11: Pars Compacta, Substantia Nigra, Neurodegeneration

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Originally described in 1817 by british physician, james parkinson, who called it "the shaking palsy. : resting tremor, problem with initiating movement, stopping and controlling movement. In 1960 the disease was traced to the loss of dopamine-producing neurons in the substantia nigra. One of the main areas that dopamine goes to inside the brain is the striatum act in adjacent brain areas drop or complete loss of dopamine levels into the striatum. Two types of parkinsons disease: early onset: caused by known genetic determinants, late onset: multifactorial. Common misconception when separating the pathology of the disease and the clinical deficits associated with parkinson symptoms: a lot of the parkinsonism symptoms associated with parkinson"s disease are caused by a, seperation between parkinson"s disease and parkinsonian symptoms. Famous parkinson"s disease patients: micheal j fox"s raised over 1 billion. Genetics hold the gun, but environment pulls the trigger e. g. oxidative stress. Classic features of parkinsonism symptoms (whether they have parkinson"s disease or not):

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