Anatomy and Cell Biology 4451F/G Lecture Notes - Lecture 9: Neurodegeneration, Blood Vessel, Oxidative Stress
6 Jun 2019
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Document Summary
Inflammation and oxidative stress play a large role in alzheimer"s disease and stroke: these two mechanisms are applicable for almost all neurodegenerative disease. Following a stroke: oxidative stress, inflammation, cell-cell communication issues, metabolic issues carries beyond just the pathogenesis of a stroke. There are two components in the blood that are essential for normal brain function (important for all cell types, not just neurons: e. g. endothelial cells wrapping the vessels, neurons, glial cells. Ischemia: drop or lack of blood flow to a specific tissue area resulting in abnormal activity (every tissue in the body needs blood for glucose, oxygen, ions) The brain is a hypermetabolic meaty organ and if it does not receive enough oxygen, glucose or other metabolites, it gets hangry . Blockage of a vessel results in lack of blood flow to specific region, resulting in an infarction: for every 100 strokes occurring, roughly 50% will have a good-full recovery (this is.
