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Lecture

Anatomy and Cell Biology 4461B Lecture Notes - Myoepithelial Cell, Acinus, Follicular Phase


Department
Anatomy and Cell Biology
Course Code
ANAT 4461B
Professor
Geordie Shepherd

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LP Lecture 4: Breast Cancer
Oncoanatomy
Normal tissue organization of a specific anatomic site that determines clinical behavior of
cancers originating from that tissue inclusive of its pattern of spread
Paradigm for oncotaxonomy - anatomical extent of spread which is the basis of cancer
classification and staging
Cancer invades in 6 directions: A-P, S-I, M-L
Cancer usually follows the “path of least resistance”
Along fascial and muscle planes
Through fatty areolar spaces
Entering low pressure lymphatics and venous channels
Key to deciding treatment and predicting outcome
Particularly histological staging
Anatomy of a Normal Breast
Breast is a modified, specialized, cutaneous glandular structure
Functions in milk production
Located in superficial fascia between second and third ribs between the sternal edge and
midaxial line
Attached via fascia to the pectoralis major
Nipple projects from anterior surface
Hyperpigmented
Mostly dense fibrous tissue covered by skin
Also contains smooth muscle fibers
Areola
Pigmented, more so during pregnancy
Montgomery tubercles
Innervation
Dermatomal
Vascular Anatomy
Internal and posterior branches of internal mammary artery
Lateral mammary branch of lateral thoracic artery
Smaller sources of arterial blood include the posterior intercostal arteries and the pec-
toral branch of the thoracoacromial artery
Wide variation between women and between breasts
Course of arteries does not appear to be associated with ductal system
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