Anatomy and Cell Biology 4429A Lecture Notes - Lecture 23: Acute Promyelocytic Leukemia, P53, Warburg Effect

• School: Western University
• Department: Anatomy and Cell Biology
• Course: Anatomy and Cell Biology 4429A
• Professor: Paul Walton

Document Summary

Cancer is a complex disease: large group of diseases, based upon the tissue of origin, further subdivisions based on genomic and proteomic profile, >10,000 mutations per cell in colon cancers, tumor stem cells. * te(cid:373) (cid:272)ells do(cid:374)"t divide very often because that would recombine the genome. This would i(cid:374)(cid:272)rease the risk of (cid:862)loss of heteroz(cid:455)gosit(cid:455)(cid:863), that allo(cid:449) for (cid:272)a(cid:374)(cid:272)erous (cid:272)ells: disease of ge(cid:374)o(cid:373)i(cid:272) i(cid:374)sta(cid:271)ilit(cid:455) (cid:894) p53(cid:895), (cid:449)hi(cid:272)h pro(cid:448)ides e(cid:454)te(cid:374)si(cid:448)e genetic variability, which is acted upon by clonal selection. But it is not always necessary to understand the complex disease in order to have effective treatments. e. g. acute promyelocytic leukemia. Defect: mutation in retinoic acid receptor- ; treatment: high levels of retinoic acid. Instead of chasing the changes, concentrate on what is required: judah folkman, md (1933 - 2008) Professor (at age 35) of cell biology at harvard medical school. Dire(cid:272)tor of the vas(cid:272)ular biolog(cid:455) progra(cid:373) at childre(cid:374)"s hospital, In 1971 published an article in the new england journal of.