Protein Folding II

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Anatomy and Cell Biology
Anatomy and Cell Biology 4429A
Paul Walton

If there is no Hsp70 in the cytoplasm the proteins will not be imported into the mitochondria The ATP requirement is for mitochondrial Hsp70 Mitochondrial Hsp70 pulls the protein across while cytosolic Hsp70 starts to release the precursor protein Hsp70 and Hsc70 are essentially interchangeable for the purposes of this course Removing Tom40I can isolate the protein and get it to the receptor but it wont go anywhere because the receptor wont hand it off to anything Peroxisomes arent endosymbionts They come from the ER Pex proteins are involved in the process of importing proteins into the peroxisome and making the peroxisomes PTS signals have different amino acids sequences Proteins with a carboxy terminal associate with PTS1 Precursor membranecomes from the endoplasmic reticulum The signals that identify peroxisomes come after this structure Pex31916 identify the precursor membrane and then more Pex proteins get added on B Because Pex12 is not there the membrane works but is not able to import things to the inside of the cell so catalase stays outside the cell The result is a ghost peroxisome C Pex3 mutants cant form the precursor structure and the result is no organelle and all membrane associated proteins in the cytoplasm The fluorescence is measuring catalase In B and C catalase is left outside the organelle and in the cytoplasm Hypotoniacant run muscles esp peripheral properly Is there more than one gene product involved in this disease Or is i
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