Biochemistry 2280A Lecture Notes - Lecture 19: Snrnp, Alternative Splicing, Interferon Alfa-2B

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Unit 4: regulation of gene expression lesson 19: rna processing (nov. 14th 2017) 5" cappi(cid:374)g: triphosphate is replaced by 7-(cid:373)ethylgua(cid:374)osi(cid:374)e at the 5" triphosphate bridge on the first base, mrnas are capped as soon as transcription happens, o(cid:374) 5" e(cid:374)d. 3" polyade(cid:374)ylatio(cid:374): almost all eukaryotic mrnas end with a long (~300 base) polya tail, recognition sequence that brings in a protein complex, cleaves rna and adds polya tail, o(cid:374) (cid:1007)" e(cid:374)d. I(cid:373)porta(cid:374)ce of the 5" cap a(cid:374)d 3" polya tail: ma(cid:396)k the 5" a(cid:374)d (cid:1007)" e(cid:374)ds of the mrna as being intact. If and rna only has a polya tail it is not intact and is garbage: required for mrna export from nucleus to cytoplasm and translation, protect the mrna from degradation. Introns are spliced out of the primary transcript to give the mature mrna: protein encoding sequences (exons) are interrupted by noncoding sequences (introns), exons are spliced together, after this, it can be translated.

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