Class Notes (839,092)
Canada (511,185)
Biochemistry (847)
Eric Ball (118)
Lecture

Acetyl CoA Part 2

2 Pages
115 Views

Department
Biochemistry
Course Code
Biochemistry 2280A
Professor
Eric Ball

This preview shows 80% of the first page. Sign up to view the full 2 pages of the document.
Description
16 – Acetyl-CoA part 2: Fatty acids, ketone bodies, and biosynthesis Release of acetyl-CoA from fatty acids storage • Low glucose conditions • Breaks down triaglycerols in adipocyte; lipase will break the fatty acids off glycerol • Fatty acids go to liver and muscle, NOT brain ○ Converted to acetyl-CoA via β -oxidation • Glycerol foes to liver ○ Fuel for gluconeogenesis Activation of fatty acids in cytosol • Fatty acyl-CoA Is transported into the mitochondrial matrix; driven by the hydrolysis of ATP β -oxidation of fatty acids in matrix • Fatty acid goes through a series of 4 cheimcal reactions  each set of reactions get an acetyl-CoA, and NADH, and FADH an2 an acyl-CoA that is 2 carbons shorter. Net reaction for acyl-CoA with:2N” carbons: Acyl-CoA + N-1 FAD + N-1 NAD+ + N-1 CoA  N Acetyl Co-A (enters CAC or in liver made ketone b+ (N-1 FADH +2N-1 NADH) ETC FADH c2mes from different sources  Each FADH gi2es electrons to Q to make QH , but2using different protein complexes β -oxidation of fatty acids: special cases • Oxidation of unsaturated fatty acids yields fewer FADH a2d may consume NADPH • Oxidation of “odd chain” fatty acids yields one propinyl-CoA, which enter the CAC as succinyl-CoA Ketone Bodies  How acetyl-CoA is transported from liver to other tissues • Brain usually likes glucose but in starvation will switch over to ketone bodies • Breaking down tricylglycerides during fasting, most acetyl-CoA made in the liver will be made into ketone bodies to be sent to the brain • Once in the brain transferred back to acetyl-CoA and goes into CAC • Muscle will also pick up ketone bodies – selfish Fatty Acid Biosynthesis • High glucose conditions – storing energy as fats
More Less
Unlock Document

Only 80% of the first page are available for preview. Some parts have been intentionally blurred.

Unlock Document
You're Reading a Preview

Unlock to view full version

Unlock Document

Log In


OR

Join OneClass

Access over 10 million pages of study
documents for 1.3 million courses.

Sign up

Join to view


OR

By registering, I agree to the Terms and Privacy Policies
Already have an account?
Just a few more details

So we can recommend you notes for your school.

Reset Password

Please enter below the email address you registered with and we will send you a link to reset your password.

Add your courses

Get notes from the top students in your class.


Submit