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Biochemistry - topic 2

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Biochemistry 2280A
Eric Ball

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BiochemTopic 2Alpha carbon is the c beside the carboxy group How a protein gets its structure dictates its function The largest ones contain an aromatic groupNet charges are important because they dictate what other proteins they can bind tocell functions Isolating one proteincharges are very importantin a cell Creating a drug by binding something to the proteincharge important The protein is surrounding by a lot of water molecules which can exchange hydrogen with the amino acidconstant dynamic movement going on within the solution with the amino acid NH2 can be NH3COO carboxy some side chains can carry a chargebut not all of themMolecule possessing a highly polar covalent bond between a hydrogen and another atom dissolves in water The hydrogen atom has given up its electron almost entirely to the companion atom and so exists as an almost naked positivelycharged hydrogen nucleus a proton When the polar molecule is surrounded by water the proton will be attracted to the partial negative charge on the O atom of an adjacent water molecule This proton can dissociate from its original partner and associate instead with the oxygen atom of the water molecule generating a hydronium ion The reverse can also occur so one has to imagine an equilibrium state in which
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