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Case Study: Antibodies

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Western University
Biochemistry 2280A
Eric Ball

Case Study AntibodiesThe antigen is the substance that causes the formation of the antibodybind together Each immunoglobin has a slight different structure Different where they have to bind IgGs if they arent similar they are variable regionsallows the antibody to bind to different antigens0hypervariable within variable are sensitive to amino acid changes 2 light chains and 2 heavy chains that make up immunoglobulineach contains a variable region and a constant region IgG is tetrameric 4 polypeptide chains but there are 2 identical pairs 2 heavy chains and 2 light chains assemble in a Y shaped formatlonger green piece is the heavy chain held together by disulfide bonds at the very tips of the light and heavy chain is the variable regionbars represented hypervariable for slots of amino acids yhpervariable regions are critical of specificity for antigen binding sitethese amino acids will be very specific to the antigen both the heavy chain and the light chain contribute to antigen binding specificity often see immunoglobulin G written as a Y because it takes that shape Various domains are the loopsfolded region withi
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