Biochemistry 2280A Lecture : Quarternary Structure

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Beta pleated sheet is made of one polypeptide chain not several wrapped around itself not several polypeptide chains. Many proteins are composed of multiple polypeptide chains or subunits. The cro- repressor for example is a homo dimer formed from 2 identical subunits. The subunits join in a head to head fashion as 2 small beta sheets, 1 form each subunit zipper up and form a larger beta sheet. Each pair of 2 subunits is held together in a head to tail fashion by repeated use of the same binding attraction. This becomes clear when the polypeptide chains are coloured in a random pattern so that the same region of each subunit have the same colours. Each subunit consents whether each neighbouring group has oxygen they communicate. Estrogen receptor b is a homo dimer because the 2 subunits are identical. P53 is a tumor suppressor gene and it is mutated in 50% of all cancers.

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