Biochemistry 2280A Lecture : Citric Acid Cycle
Document Summary
Outer membrane is composed of lipids pore made of proteins (allow some molecules across). Outter membrane is leaky small molecules can get across readily, but larger proteins cant. Inner membrane is a tighter seal won t allow polar molecules to cross unless a special pathway exists. Atp synthesis/most of the reactions occur here therefore a higher surface area. Space inbetween the inner and outer membrane is the intermembrane space. Individual cristae not linear quite extensive; have some volume to them. Early on before prokaryotic/eukaryotic split mitochondria came into a symbiotic relationship with a larger cell. Mitochondria reproduce by splitting; they have their own genome; for these reasons we believe they have evolved from bacteria. Mitochondria also has 2 membranes just as bacteria do. Last 2 carbons get oxidized in the citric acid cycle. Pyruvate and oxygen go through a series of reactions to get the final products. Stage 2. citric acid cycle last 2 carbons get oxidized.