Biochemistry 2280A Lecture : Topic 16

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Glucose made in the liver by gluconeogenesis and fats from. Hormone sensitive lipase cleaves the fatty acid from the glycerol. Under low glucose conditions liver is getting the most. Fatty acids have to go from the bloodstream to the cell; have to get them into the mitochondrial matrix. Acetyl coa transfers fatty acids high energy bond between the acetyl coa and fatty acid need a high energy input to form the bond. Add a double bond which gives an fadh2 (oxidation reaction there is the reduction). Add water to make an alcohol another redox reaction; alcohol is oxidized toa ketone so nad is reduce to nadh. Another co-enzyme a can attack the carbon and kick of a 2 carbon acetyl group get the fatty acid chain but you ve lost 2 carbons on the acid. Cell isnt stuck on using normal fatty acids can handle other acids. 3c odd number of carbons body can handle it.

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