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Topic 21

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Biochemistry 2280A
Eric Ball

Topic 21Larger the molecule more chance of errors Cell treats all DNA changes as badcell inherited DNA from another cell so it should be the sametry to preserve itMissed the wrong base pair didnt fix it Top strand is going to be used as a template for synthesis of the offspring have a mutation which is now permanent no way to recognize that this is a problem because they have the correct pairs Deamination is a chemical reaction in which you lose an amine group and it is converted to a carbonyl Get uracil and not cytosine This is why we dont have uracil in our DNAhow do you know if the U or the G is wrong This is why we dont have bothTend to change a CG into a TA Losing a purineonly the base Break the glycosidic bond This is called an Abasic site because you are missing the base in yellow on the right Nothing therewhen you do replication there is no base there This can cause cell death because the DNA needs to be fully replicated This is why we have translesion DNA polymeraseDNApolymerase stops because there is no base These polymerase go on they can go past this problem They can go by these lesions but they are more error proneDont know which base to put in because there is no way of knowing guesses Can put any base pair in All other previous are energetically favourablewill happen Makes a 4 member carbon
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