Biochemistry 2280A Lecture : Topic 21
26 Dec 2011
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Cell treats all dna changes as bad cell inherited dna from another cell so it should be the same try to preserve it. Missed the wrong base pair (didn t fix it). Top strand is going to be used as a template for synthesis of the offspring have a mutation which is now permanent; no way to recognize that this is a problem (because they have the correct pairs). Deamination is a chemical reaction in which you lose an amine group and it is converted to a carbonyl. Tend to change a cg into a ta. This is called an a-basic site because you are missing the base (in yellow on the right). Nothing there when you do replication there is no base there. This can cause cell death because the dna needs to be fully replicated. This is why we have translesion dna polymerase dna polymerase stops because there is no base.
