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Lecture

Mutations

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Department
Biochemistry
Course
Biochemistry 2280A
Professor
Eric Ball
Semester
Fall

Description
MutationsMissense mutation We got rna sequence wild typefirst is mutation where we put GCC as GGCsingle base mutation What does this do for proteinresults in single amino acid change from alanine to glycineAlanine and glycine are functionally similarnot identical but similargood chance that glycine might allow for functional protein If alanine were converted to arganine or something elsetheres higher chance that protein is dysfunctional Results in single amino acid change May affect protein function but it may notFrame shift mutationaddition of one two or three bases Insertion of one baseAinto that codeframe shift could be isnertion of one or two or taking away one or two basesadding three or taking away three would either add or delete full codon and thats a full amino acidthis may be or may not be deleteriousdepends on protein What does frameshift mutatino do to protein It changes the encoded protein
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