Biochemistry 2288A Lecture Notes - Steric Effects, Covalent Bond, Beta Sheet

• School: Western University
• Department: Biochemistry
• Course: Biochemistry 2288A
• Professor: Derek Mc Lachlin

Document Summary

1-6, 11-22, 26-35: central dogma, amino acids, protein structure, protein function, enzyme catalysis, protein purification. Peptide bond amino acids are connected by a covalent peptide bond. > results in a "polypeptide backbone" of repeating ncc-ncc-ncc- units. > side chains of residues project outwards from the backbone the properties of the side chains of individual residues gives characteristics to the polypeptide chain. > some side chains are hydrophilic/hydrophobic, etc due to resonance from the c=o and c-n bond the peptide bond exhibits characteristics of a double bond. > restricts movement around the c-n peptide bond. > sequence of residues making up the protein chain. > residues linked by covalent bonds only minimum size of a protein sequence is 50 residues. Anything smaller is just a peptide average molecular weight of a residue is 110da no theoretical largest size largest protein so far discovered has 30 000 residues. > describes local folding patterns of the polypeptide backbone.