Biochemistry 3381A Lecture Notes - Lecture 1: Van Der Waals Force, Covalent Bond, Bond Length
13 Nov 2016
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Proteins lec 1: water properties and interactions sp3 hybridized o charge distribution, strong dipole both h-bond donor and acceptor unusual properties. Formed by functional groups containing strongly electronegative atoms. Sum of van der waals radii of o and h =2. 6 . H-bonds can occur b/w groups, or with water. Protein in water: large number of potential h-bonds. Arise from asymmetric electron distribution permanent or transient. 1. 13 the van der waals interaction energy as a function of the distance r between the centres of two atoms. Each h2o molecule makes 4 h-bonds- a crystalline lattice with molecules less densely packed than in liquid water. Liquid water: h-bonded oligomers liquid water is not individual molecules, but oligomers liquid water is heavily h-bonded: at zero degrees, about 85% of h-bonds are retained. Oligomers are transient h-bonds form/break on a timescale of 10^-11 s. Behaves like it has a higher molecular weight high melting point and boiling points.
