Biochemistry 2280A Lecture : 22 Gene Expression 2012.docx

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In any one cell type ~10,000 are expressed things. E. g. a muscle cell is different from a liver cell because they each express a different. 10 000 genes, with some genes overlapping but at least some different ones: correct gene expression is essential for normal cell health. If we have incorrect gene expression, will result in diseased phase: out of the blueprint of life, expressed genes is how we define life itself. Most disease states, most notably cancer, result from or are manifest by alterations in expression of one or more genes. By manipulating gene expression profiles, we have the potential to prevent or reverse disease states. So if we have something expressed in incorrect amount or wrong places will result in diseases and can often be traced back to defects in gene expression. So if we can change the gene expression profile back to normal, we have a good chance of reversing the diseased state.

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