Biochemistry 2280A Lecture Notes - Lecture 13: Oxidative Phosphorylation, Inner Mitochondrial Membrane, Peripheral Membrane Protein

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Oxidative process to make atp = oxidative phosphorylation. Prosthetic group: tightly bound cofactor permanently associated: could be metal ion or coenzyme, never dissociated from enzyme. Incorporated as part of the enzyme while some cofactors will come and go. Have nadh and fadh2 from the citric acid cycle (pyruvate oxidation) Have electrons and they"re given up in the etc: several large protein complexes that are in the inner mitochondrial membrane, electrons are transferred as they go through a series of electron acceptors. Intermembrane space: space between the inner and outer membrane. Final product: electrons get transferred to oxygen to make water and nad+ and fadh go back to be used. Transfer of electrons in an order that is energetically favorable. Purpose: move protons from matrix intermembrane space to make atp: create a larger concentration of protons in the intermembrane space than the matrix = source of potential energy, concentration/electrical difference. Electrons passed from one thing to another in a defined order.

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