Biochemistry 2280A Lecture Notes - Lecture 6: Metachromatic Leukodystrophy, Classical Genetics, Dna Profiling
10 Dec 2016
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Document Summary
The techniques that recombine dna fragments from different sources into new molecules with unique features. Engineering of biological systems, with the goal of carrying out novel functions or performing existing functions more efficiently. Humans have been doing it for 1000s of years through classical genetic selection. Plant/crop/livestock breeding are examples of humans manipulating the dna of other organisms. Classical genetics is slow (limited buy the breeding times of the organism and the chance genetic events), and exchange of genetic materials is limited to breeding species. Recombinant dna is rapid (as quick as a few days in some organisms), no limitations. Significance of recombinant dna technology: research key tool to understand cell and molecular structure/function, biotechnology major impact on society. Human insulin, human growth hormone, vaccines, artemisinin (malaria), interleukins. Diagnosis of disease detect pathogens and disease causing genes through their dna signatures.
