Biochemistry 2280A Lecture Notes - Lecture 21: Nuclear Matrix, Histone H2A, Arginine

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Topic 18 continued: difference between dna and rna. Dna has deoxyribose, while rna is based on ribose. This makes rna unstable in basic solution, while dna is stable. Dna has thymine, rna has uracil (lacks a methyl group but it pairs with adenine just like thymine) In general, dna strands are longer than rna strands. If you put rna into solution, it"ll base pair with itself forms irregular structure that"s dependent on sequence (dna isn"t sequence-dependent) Nitrogenous bases (stuff that"s stuck onto the sugar = a/c/u/g) are more likely to be modified in rna than dna, and the variety of modifications is larger: rna structure. Has modified bases primary structure folds up (the single strand looks for complementary bases within itself become secondary structure. Hairpin/stem-loop structure is the little loop it makes trna is usually a cloverleaf shape (3 loops) Example: small subunit ribosomal rna (thermus thermophilus) Dna structure is sequence-dependent (like proteins, unlike dna)

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