Biochemistry 2280A Lecture Notes - Lecture 19: Main Source, Insulin Resistance, Sedentary Lifestyle
12 Dec 2016
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Topic 16 continued: fatty acid metabolism: low glucose. Body recognizes that it doesn"t have much energy mobilizes fatty acid storage. This process takes a while to get going. The brain and body is primed to get energy through glycerol. In order to start fatty acid metabolism, it takes a few days to make all the necessary enzymes etc. Sort of a slower response to low glucose. Once glucose rises insulin produced this process is shut down: precursors for synthesis. We can take metabolites that are in the central energy metabolic pathways and use them to make other things. E. g. amino acids, purine and pyrimidine (dna) Glycolysis and citric acid cycle provide precursors for synthesis of many biomolecules. Under high glucose conditions when biosynthesis is favoured, carbons will be taken away to make other things. Generally when glucose and insulin is high: example: cholesterol synthesis. All of the carbons in cholesterol ultimately come from acetyl-coa.
