Biochemistry 2280A Lecture Notes - Lecture 8: Outline Of Academic Disciplines, Neuraminidase Inhibitor, Innate Immune System
12 Dec 2016
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Analogues = compounds that resemble the transition state (similar geometry and charge distribution) but they don"t undergo a chemical reaction. Mimic original substrate and bind to the receptor site block the original substrate. Excellent inhibitors because they bind tightly block the active site. Many drugs/antibiotics are enzyme inhibitors, most effective if they are transition state analogs. Oseltamivir (tamiflu): flu medication that"s a neuraminidase inhibitor. Prevents flu virus from releasing itself from the host cell: enzymes function best under optimal conditions. Bell shaped curve = instability of enzyme at extremes of temperature/ph: lysozyme: example of catalytic mechanism. Lysozyme was one of the first enzyme of which the reaction mechanism was figured out. Found in tears, saliva, mucus and eggs and has antibacterial properties. It hydrolyzes a polysaccharide found in the cell walls of some bacteria. Stabilized by disulfide bonds: lysozyme cleaves a polysaccharide chain that"s in the cell wall of bacteria.
