Class Notes (903,427)
CA (537,988)
Western (51,517)
Biochemistry (865)
2280A (652)
Eric Ball (119)
Lecture 5

Biochemistry 2280A Lecture 5: 5 - Enzyme Catalysis

3 Pages

Course Code
Biochemistry 2280A
Eric Ball

This preview shows page 1. Sign up to view the full 3 pages of the document.

Loved by over 2.2 million students

Over 90% improved by at least one letter grade.

Leah — University of Toronto

OneClass has been such a huge help in my studies at UofT especially since I am a transfer student. OneClass is the study buddy I never had before and definitely gives me the extra push to get from a B to an A!

Leah — University of Toronto
Saarim — University of Michigan

Balancing social life With academics can be difficult, that is why I'm so glad that OneClass is out there where I can find the top notes for all of my classes. Now I can be the all-star student I want to be.

Saarim — University of Michigan
Jenna — University of Wisconsin

As a college student living on a college budget, I love how easy it is to earn gift cards just by submitting my notes.

Jenna — University of Wisconsin
Anne — University of California

OneClass has allowed me to catch up with my most difficult course! #lifesaver

Anne — University of California
find more resources at Tuesday, September 22, 2015 Enzyme Catalysis Meakin Lecture 6 By the end of today: - describe what an enzyme is and how it accelerates biochemical reactions - understand the different types of reactions that enzymes can perform - understand what catalysts do Enzyme Catalysis - biological catalysts • perform nearly all chemical transformations in cells • accelerate, but are unchanged by, a reaction - most enzymes are proteins - name often ends in 'ase‘ (eg. protease) - often extremely specific • they have ‘targeted’ or restricted ligands (called substrates) • substrate: the molecule on which an enzyme acts - enzymes carry out a limited number of chemical reactions Types of Chemical Reactions Carried Out by Enzymes - hydrolytic — cleavage using water • nucleases, proteases, phosphatases - condensation — connect molecules together • polymerases, synthases - isomerization — rearrange bonds • isomerases - oxidation-reduction — gain or loss of electrons • oxidases, reductases, dehydrogenases - group transfer — transfer chemical group • phosphorylation, sumolyation, acetylation, glycosylation Enzymes Act On But Are Unchanged By Substrates Active Site of Enzymes - part of the enzyme where the reaction takes place • small part of enzyme surface (5% or less) • often a cleft or crevice between domains - substrate binds in active site • multiple weak bonds • dissociates from enzyme ▯1 find more resources at find more resources at Tuesday, September 22, 2015 How Do Enzymes Catalyze Reactions? - must understand a transition state - the transition state of a chemical reaction is defined as the state corresponding to the highest energy along the reaction coordinate - at this point, assuming a perfectly irreversible reaction, colliding reactant molecules will always go on to form products - the transition state is: • an intermediate form between reactants and products • a transient, high-energy state • a form different from reactants & products Enzyme Catalysis - the speed of a reaction is determined by how difficult it is to get to the transition state - enz
More Less
Unlock Document

Only page 1 are available for preview. Some parts have been intentionally blurred.

Unlock Document
You're Reading a Preview

Unlock to view full version

Unlock Document

Log In


Don't have an account?

Join OneClass

Access over 10 million pages of study
documents for 1.3 million courses.

Sign up

Join to view


By registering, I agree to the Terms and Privacy Policies
Already have an account?
Just a few more details

So we can recommend you notes for your school.

Reset Password

Please enter below the email address you registered with and we will send you a link to reset your password.

Add your courses

Get notes from the top students in your class.