Biochemistry 2280A Lecture Notes - Lecture 10: Pyruvate Dehydrogenase, Lipid Bilayer, Coenzyme A
15 Jan 2017
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Pyruvate -> acetyl-coa and co2, citric acid cycle. Used to be a symbiotic bacteria but was consumed and taken up by the eukaryotic cell to become the mitochondria. Small, polar molecules (<5000 dalton) can pass through pores without problem. Much larger surface area due to the folds (cristae) Good because this is where the action takes place. Space that is enclosed by the inner membrane. Separated from the matrix and the cytosol. Pyruvate + o2 -> -> -> -> -> co2 + h2o. Pyruvate carbons are completely oxidized to co2. Acetyl-coenzyme a is modified with an acetyl group. Reacts with fatty acids (like the acyl) and carries them around. You need to recognize molecules when broken (coenzyme a vs atp vs nadph vs nadh etc) Pyruvate + nad+ + coa ---[pyruvate dehydrogenase]--> Pyruvate dehydrogenase only catalyzes the forward reaction. Pyruvate dehydrogenase complex: 60 polypeptide chains, 3 different enzymes. Dividing point between fatty acid metabolism and carbohydrate metabolism.
