Biochemistry 2280A Lecture Notes - Lecture 10: Insulin, Citric Acid Cycle, Citric Acid
13 Feb 2017
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Pyruvate made in cytosol gets transported to mitochondria. Mitochondria have their own small genome (less than 40 genes) Once in the past was a free living organism. Outer membrane= lipid bilayer and has big pores (small polar molecules (<50daltons) can easily pass through) Lipid bilayer has no pores but has membrane proteins. Has folds to increase surface area for a lot of reactions to happen. Matrix=the inside, where the pyruvate is transported to. Pyruvate + o2 going to co2 + h2o (oxidizing pyruvate to co2) Coenzyme a-carrier molecule (has adenine) (modified at sh) Pyruvate dehydrogenase enzyme takes 1/3 carbons from pyruvate and oxidizes to co2, then takes electrons and places them on nad+ to make nadh, the other 2 electrons get attached to coa to make acetyl coa. An irreversible reaction (no enzyme to catalyze reverse process) Took a carbohydrate and made to fatty acid (acetyl coa)
