Biochemistry 2280A Lecture Notes - Lecture 19: Gene Expression, Rna Editing, Central Dogma Of Molecular Biology

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Information is stored in dna in the form of genes. The human genome encodes 25000 different protein encoding genes. In any one cell type 10000 are expressed at various levels the expression of the correct genes is essential for growth and differentiation of all cells: right genes must be there. Most disease states, ie cancer are due to altered expression of one or more genes. By manipulating gene expression, we have the potential to prevent or reverse disease. Brain and liver have same genes: but don"t express the same proteins, major differences: In brain: protein that is highly expressed has little to no expression in liver. Genetic info flows from dna to rna to protein. Gene expression can be regulated more than 8 times in eukaryotic cells. Rna step in gene expression in eukaryotic ell: Dna to rna to protein: the rna step allows genes to be expressed at different levels.

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